Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 | P28472 | 20/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 18/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 18/20 | 0.43 |
| ▸ | GABRP | O00591 | 16/20 | 0.43 |
| ▸ | GABRD | O14764 | 16/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 16/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 16/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 16/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 16/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 16/20 | 0.43 |
| ▸ | GABRE | P78334 | 16/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 16/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 16/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 16/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 16/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL921378 | 0.94 | GABRB3 (0.39) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL4082183 | 0.90 | GABRB3 (0.47) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL3366234 | 0.89 | GABRB3 (0.42) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL3367279 | 0.89 | GABRB3 (0.42) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL6055815 | 0.86 | GABRB3 (0.47) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL711450 | 0.85 | GABRB3 (0.41) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL3975269 | 0.85 | GABRB3 (0.44) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL6055924 | 0.83 | GABRB3 (0.44) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL4415803 | 0.82 | GABRB3 (0.42) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL9010483 | 0.80 | GABRB3 (0.43) | GABRB3GABRA2GABRB2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069571-A1 | Process for the Preparation of 5-Alkylthioalkylamino-I-Phenyl-Pyrazoles | MERIAL LIMITED | 2009-03-12 | — | — | US | disclosed |
| EP-1879869-B1 | PROCESS FOR THE PREPARATION OF PRECURSORS OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | MERIAL LTD (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20080281107-A1 | Process for the preparation of 5-alkylthioalkylamino-I-phenyl-pyrazoles | MERIAL LIMITED | 2008-11-13 | — | — | US | disclosed |
| EP-1879869-A1 | PROCESS FOR THE PREPARATION OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | Merial Limited (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006119862-A1 | PROCESS FOR THE PREPARATION OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | MERIAL LTD. (US) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080281107-A1 | Process for the preparation of 5-alkylthioalkylamino-I-phenyl-pyrazoles | CYP3A5, CYP1A1, CYP3A4 | GABRB3 1832/4885GABRA2 2050/4885GABRB2 2518/4885 |
| US-20090069571-A1 | Process for the Preparation of 5-Alkylthioalkylamino-I-Phenyl-Pyrazoles | CYP3A5, CYP1A1, CYP3A4 | GABRB3 1832/4885GABRA2 2050/4885GABRB2 2518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.