SCHEMBL396465

SCHEMBL396465

CNC(=O)N1c2ccc(C)cc2Sc2cc(C)cc(N)c21

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ BCHE P06276 11/20 0.47
▸ ACHE P22303 1/20 0.47
▸ CREBBP Q92793 1/20 0.36
▸ NOX1 Q9Y5S8 1/20 0.34
▸ MAPT P10636 4/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ SNCA P37840 2/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ HPGD P15428 1/20 0.33
▸ ALOX12 P18054 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ MAPK1 P28482 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32
▸ L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1926809 0.87 NOX1 (0.44) BCHEACHENOX1MAPTSMN1; SMN2
SCHEMBL1828807 0.84 BCHE (0.37) BCHEACHEMAPTKMT2AGAA
SCHEMBL18906407 0.70 BCHE (0.63) BCHEMAPTMEN1KMT2AHPGD
SCHEMBL396463 0.69 BCHE (0.61) BCHEACHENOX1MAPTSMN1; SMN2
SCHEMBL244827 0.67 MAPK1 (0.62) BCHEACHEMAPTSNCAMEN1
SCHEMBL29384821 0.67 MAPK1 (0.62) BCHEACHEMAPTSNCAMEN1
SCHEMBL17356853 0.67 BCHE (0.41) BCHEACHENOX1MAPTSMN1; SMN2
SCHEMBL17356860 0.66 BCHE (0.67) BCHEMAPTMEN1KMT2AHPGD
SCHEMBL1207990 0.65 NOX1 (0.41) BCHEACHENOX1MAPTSNCA
SCHEMBL17356855 0.64 BCHE (0.66) BCHEACHENOX1SMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020123150-A1 Method COLGATE-PALMOLIVE COMPANY 2002-09-05 — — US claimed
WO-2002051362-A2 METHOD COLGATE-PALMOLIVE COMPANY (US) 2002-07-04 — — WO claimed
US-5223404-A Chromogen, oxidase, compound which releases rate enhancer in presence of peptidase SUNSTAR KABUSHIKI KAISHA (JP) 1993-06-29 — — US claimed
US-12264356-B2 Method for determining sensitivity to SGLT2 inhibitor and sensitivity marker for SGLT2 inhibitor NIHON UNIVERSITY (JP) 2025-04-01 — — US disclosed
EP-3461907-B1 MEASUREMENT OF GLYCOPROTEIN ARKRAY INC (JP) 2023-06-14 — — EP disclosed
US-10989714-B2 Measurement of glycoprotein ARKRAY, INC. (JP) 2021-04-27 — — US disclosed
US-20200347458-A1 METHOD FOR DETERMINING SENSITIVITY TO SGLT2 INHIBITOR AND SENSITIVITY MARKER FOR SGLT2 INHIBITOR NIHON UNIVERSITY (JP) 2020-11-05 — — US disclosed
US-20190137502-A1 Measurement of Glycoprotein ARKRAY, INC. (JP) 2019-05-09 — — US disclosed
EP-3461907-A1 MEASUREMENT OF GLYCOPROTEIN ARKRAY, Inc. (JP) 2019-04-03 — — EP disclosed
EP-2319937-B1 BLOOD COMPONENT MEASUREMENT METHOD UTILIZING HEMOLYZED WHOLE BLOOD, AND KIT FOR THE METHOD NIPPON KAYAKU KK (JP) 2016-01-27 — — EP disclosed
US-8999124-B2 Detection device NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2015-04-07 — — US disclosed
US-5426033-A Accurate quantitative analysis KYOWA MEDEX CO., LTD. (JP) 1995-06-20 — — US disclosed
EP-0608795-A1 Method for enzymatic determination of substrate after enzymatically removing galactose Kyowa Medex Co. Ltd. (JP) 1994-08-03 — — EP disclosed
US-5334507-A Pyruvate kinase, glycerol kinase, glycerol-3-phosphate oxidase, peroxidase, reduced chromogen, adenosine diphosphate, phosphoenolpyruvic acid TOYO BOSEKI KABUSHIKI KAISHA (JP) 1994-08-02 — — US disclosed
EP-0533183-A2 Composition for the measurement of potassium ion concentration TOYO BOSEKI KABUSHIKI KAISHA Trading under the name of Toyobo Co., Ltd. (JP) 1993-03-24 — — EP disclosed
EP-0174371-B1 TRIPHENYLMETHANE DERIVATIVES AND METHOD FOR DETERMINING OXIDATIVE SUBSTANCES USING THEM AS COLOR-FORMING COMPONENT WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 1990-09-19 — — EP disclosed
US-4778753-A IN PRESCENCE OF URICASE, METAL CHELATE AND ANIONIC SURFACTANT; WITHOUT COLORING INTERFERENCE WAKO PURE CHEMICAL INDUSTRIES LTD. (JP) 1988-10-18 — — US disclosed
US-4673635-A Triphenyl methane derivatives and method of quantitatively measuring an oxidative substance WAKO PURE CHEMICAL INDUSTRIES LTD. (JP) 1987-06-16 — — US disclosed
US-4613465-A HYDROGEN PEROXIDE, BODY FLUIDS, ENZYMES WAKO PURE CHEMICAL INDUSTRIES LTD. (JP) 1986-09-23 — — US disclosed
EP-0174371-A1 TRIPHENYLMETHANE DERIVATIVES AND METHOD FOR DETERMINING OXIDATIVE SUBSTANCES USING THEM AS COLOR-FORMING COMPONENT WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 1986-03-19 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10989714-B2 Measurement of glycoprotein ENGASE, UGGT1, ST6GAL1 BCHE 703/4885ACHE 1316/4885CREBBP 4043/4885
US-20190137502-A1 Measurement of Glycoprotein ENGASE, UGGT1, ST6GAL1 BCHE 703/4885ACHE 1316/4885CREBBP 4043/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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