Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 2/20 | 0.46 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | DRD3 | P35462 | 5/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | CCR3 | P51677 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715696 | 0.91 | FPR2 (0.47) | FPR2PROKR1EPHX2TBK1HTR2A | |
| SCHEMBL3960275 | 0.91 | FPR2 (0.47) | FPR2PROKR1EPHX2TBK1HTR2A | |
| SCHEMBL3963467 | 0.89 | HRH1 (0.43) | TBK1DRD3HRH1CCR3KCNH2 | |
| SCHEMBL14715698 | 0.87 | FPR2 (0.47) | FPR2PROKR1EPHX2TBK1HTR2A | |
| SCHEMBL3960280 | 0.87 | FPR2 (0.47) | FPR2PROKR1EPHX2TBK1HTR2A | |
| Hydrochloric Acid SCHEMBL3074546 | 0.86 | FPR2 (0.46) | FPR2PROKR1EPHX2TBK1HTR2A | |
| Hydrochloric Acid SCHEMBL3074547 | 0.86 | FPR2 (0.46) | FPR2PROKR1EPHX2TBK1HTR2A | |
| SCHEMBL3963626 | 0.86 | MEN1 (0.46) | EPHX2HTR2ADRD3HRH1CCR3 | |
| SCHEMBL3067847 | 0.84 | DRD3 (0.53) | FPR2PROKR1HTR2ADRD3 | |
| SCHEMBL3067843 | 0.84 | DRD3 (0.53) | FPR2PROKR1HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |
| EP-2079693-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. Hoffmann-Roche AG (CH) | 2009-07-22 | — | — | EP | claimed |
| WO-2008052899-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | WO | claimed |