Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 6/20 | 0.45 |
| ▸ | CDK2 | P24941 | 6/20 | 0.45 |
| ▸ | CDK9 | P50750 | 6/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.45 |
| ▸ | JAK2 | O60674 | 8/20 | 0.44 |
| ▸ | JAK3 | P52333 | 7/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 4/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.39 |
| ▸ | CDK7 | P50613 | 3/20 | 0.39 |
| ▸ | CCNH | P51946 | 3/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966018 | 0.94 | CCNT1 (0.42) | CCNT1CDK2CDK9CCNA2JAK2 | |
| SCHEMBL3960896 | 0.93 | CCNA2 (0.46) | CCNT1CDK2CDK9CCNA2JAK2 | |
| SCHEMBL3966699 | 0.88 | CDK9 (0.42) | CCNT1CDK2CDK9CCNA2JAK2 | |
| SCHEMBL3965200 | 0.87 | AXL (0.41) | JAK2JAK3CHRNB2CHRNA4JAK1 | |
| SCHEMBL13881451 | 0.87 | AXL (0.53) | CCNT1CDK2CDK9CCNA2JAK2 | |
| SCHEMBL3969743 | 0.82 | AXL (0.42) | JAK2JAK3CHRNB2CHRNA4JAK1 | |
| SCHEMBL3968736 | 0.82 | JAK2 (0.44) | CCNT1CDK2CDK9CCNA2JAK2 | |
| SCHEMBL3968635 | 0.81 | AXL (0.39) | JAK2JAK3JAK1TYK2CDK1 | |
| SCHEMBL3968343 | 0.81 | JAK2 (0.52) | CDK9JAK2JAK3JAK1TYK2 | |
| SCHEMBL3966826 | 0.81 | AXL (0.53) | CCNT1CDK2CDK9CCNA2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |