Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 11/20 | 0.46 |
| ▸ | CDK2 | P24941 | 11/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.46 |
| ▸ | CDK9 | P50750 | 10/20 | 0.46 |
| ▸ | CDK1 | P06493 | 7/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.46 |
| ▸ | CDK7 | P50613 | 7/20 | 0.46 |
| ▸ | CCNH | P51946 | 7/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 4/20 | 0.39 |
| ▸ | CCND1 | P24385 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.38 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969931 | 0.93 | CCNT1 (0.45) | CCNA2CDK2CCNT1CDK9CDK1 | |
| SCHEMBL3965200 | 0.88 | AXL (0.41) | CDK1AXLBRD4JAK2BRD2 | |
| SCHEMBL3966826 | 0.88 | AXL (0.53) | CCNA2CDK2CCNT1CDK9CDK1 | |
| SCHEMBL3966018 | 0.87 | CCNT1 (0.42) | CCNA2CDK2CCNT1CDK9CDK1 | |
| SCHEMBL3969743 | 0.83 | AXL (0.42) | AXLBRD4JAK2JAK3 | |
| SCHEMBL3968736 | 0.83 | JAK2 (0.44) | CCNA2CDK2CCNT1CDK9CDK1 | |
| SCHEMBL3966699 | 0.82 | CDK9 (0.42) | CCNA2CDK2CCNT1CDK9CDK1 | |
| SCHEMBL3968343 | 0.82 | JAK2 (0.52) | CDK9CDK7AXLCDK4FGFR1 | |
| SCHEMBL3971087 | 0.81 | AXL (0.41) | AXLBRD4JAK2JAK3 | |
| SCHEMBL3968635 | 0.81 | AXL (0.39) | CDK1AXLBRD4JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |