SCHEMBL396532

SCHEMBL396532

C=C(C)C(=O)OC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](COC(=O)C(=C)C)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.47
ALDH1A1 P00352 2/20 0.42
THRB P10828 1/20 0.40
POLB P06746 1/20 0.30
APEX1 P27695 1/20 0.30
HTT P42858 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL396761 0.98 TSHR (0.48) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL9714988 0.91 TSHR (0.43) TSHRALDH1A1THRB
SCHEMBL17236328 0.91 TSHR (0.43) TSHRALDH1A1THRB
SCHEMBL18965500 0.89 TSHR (0.40) TSHRALDH1A1THRB
SCHEMBL396292 0.89 ALDH1A1 (0.43) TSHRALDH1A1THRB
SCHEMBL10793301 0.83 TSHR (0.36) TSHRALDH1A1THRB
SCHEMBL1046024 0.82 TSHR (0.44) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL9411488 0.82 TSHR (0.44) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL332603 0.82 TSHR (0.44) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL10794308 0.82 TSHR (0.36) TSHRALDH1A1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8110697-B2 Method for the production of polymerizable silicones WACKER CHEMIE AG (DE) 2012-02-07 US disclosed
US-8101789-B2 Method for the production of polymerizable silicones WACKER CHEMIE AG (DE) 2012-01-24 US disclosed
EP-2125833-B1 METHOD FOR THE PRODUCTION OF POLYMERISABLE SILICONES WACKER CHEMIE AG (DE) 2010-08-25 EP disclosed
EP-2125834-B1 METHOD FOR THE PRODUCTION OF POLYMERISABLE SILICONES WACKER CHEMIE AG (DE) 2010-08-25 EP disclosed
US-20100041909-A1 METHOD FOR THE PRODUCTION OF POLYMERIZABLE SILICONES WACKER CHEMIE AG (DE) 2010-02-18 US disclosed
US-20100029972-A1 METHOD FOR THE PRODUCTION OF POLYMERIZABLE SILICONES WACKER CHEMIE AG (DE) 2010-02-04 US disclosed
EP-0242080-B1 COPOLYMER COMPOSITIONS PARAGON OPTICAL INC (US) 1992-12-16 EP disclosed
US-5087392-A Controlled cast molding; interrupting polymerization of first mixture of vinyl monomers by reacting with second; heating; efficient SOLA USA, INC. (US) 1992-02-11 US disclosed
EP-0192683-B1 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE PARAGON OPTICAL INC (US) 1989-12-20 EP disclosed
EP-0184924-B1 LENS COMPOSITION, ARTICLES AND METHOD OF MANUFACTURE PARAGON OPTICAL INC (US) 1988-11-30 EP disclosed
US-4769431-A Polyacryloxyalkylsilanol lens composition, articles and method of manufacture PARAGON OPTICAL INC. (US) 1988-09-06 US disclosed
EP-0242080-A2 Copolymer compositions PARAGON OPTICAL INC (US) 1987-10-21 EP disclosed
US-4661573-A INTRAOCULAR AND CONTACT LENSES; COPOLYMER OF PERFLUROALKYL ACRYLATE, ACRYLOXYALKYLPOLYSILOXANE, ACRYLOXYALKYLSILANOL, POLYACRYLOXYALKYLPOLYSILOXANE PARAGON OPTICAL INC. (US) 1987-04-28 US disclosed
US-4582884-A Lens composition, article and method of manufacture PARAGON OPTICAL, INC. (US) 1986-04-15 US disclosed