Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | POLR1A | O95602 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28932975 | 0.79 | TACR1 (0.51) | USP30CCR8 | |
| SCHEMBL23951570 | 0.79 | TACR1 (0.51) | USP30CCR8 | |
| SCHEMBL3962470 | 0.77 | TRPV1 (0.48) | TRPV1KDM4EEPHX1 | |
| SCHEMBL4472332 | 0.77 | CCR5 (0.43) | TRPV1KDM4EEPHX1 | |
| SCHEMBL29773631 | 0.77 | METAP1 (0.46) | TRPV1BRD4 | |
| SCHEMBL23951633 | 0.76 | TACR1 (0.52) | TRPV1CCR8 | |
| SCHEMBL21640652 | 0.76 | USP30 (0.50) | USP30POLR1AADORA2AADORA2B | |
| SCHEMBL1351433 | 0.74 | USP30 (0.55) | TRPV1USP30EPHX1 | |
| SCHEMBL13865711 | 0.73 | DRD2 (0.45) | TRPV1KDM4ECA12CA1CA2 | |
| SCHEMBL13870115 | 0.71 | PAK1 (0.49) | TRPV1KDM4EEPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528150-B2 | Urea derivatives having vanilloid receptor antagonist activity | GLAXO GROUP LIMITED (GB) | 2009-05-05 | — | — | US | disclosed |
| US-20060178397-A1 | Urea derivatives having vanilloid receptor antagonist activity | GLAXO GROUP LIMITED (GB) | 2006-08-10 | — | — | US | disclosed |
| EP-1608640-A2 | UREA DERIVATIVES HAVING VANILLOID RECEPTOR ANTAGONIST ACTIVITY | GLAXO GROUP LIMITED (GB) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004078101-A2 | UREA DERIVATIVES HAVING VANILLOID RECEPTOR ANTAGONIST ACTIVITY | GLAXO GROUP LIMITED (GB) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178397-A1 | Urea derivatives having vanilloid receptor antagonist activity | UTS2R, TRPV1, TACR1 | TRPV1 2/4885USP30 919/4885CCR8 2344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.