Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966081 | 0.85 | KDM4E (0.47) | GAALMNAKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL3964180 | 0.81 | NPC1 (0.42) | LMNAMAPTTP53SMN1; SMN2NPC1 | |
| SCHEMBL3966975 | 0.77 | HTT (0.39) | LMNANPC1RAB9ACCNA2CDK2 | |
| SCHEMBL3959574 | 0.76 | CYP1A2 (0.46) | LMNAMAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL3956114 | 0.75 | KMT2A (0.42) | MAPTPOLBKDM4ENPC1RAB9A | |
| SCHEMBL3968445 | 0.74 | HRH3 (0.47) | GAAATMLMNAMAPTPOLB | |
| SCHEMBL3959493 | 0.74 | NAMPT (0.44) | LMNATP53POLBKDM4ESMN1; SMN2 | |
| SCHEMBL2089950 | 0.73 | NPY5R (0.34) | NPY5RGAAATMNPC1RAB9A | |
| SCHEMBL3966365 | 0.72 | TGM2 (0.43) | POLBKCNH2 | |
| SCHEMBL3956362 | 0.72 | EPHX2 (0.41) | GAALMNACNR1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069346-A1 | ACETAMIDE AND CARBOXAMIDE DERIVATIVES OF AZAADAMANTANE AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008118743-A1 | ACETAMIDE AND CARBOXAMIDE DERIVATIVES OF AZAADAMANTANE AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2008-10-02 | — | — | WO | disclosed |