Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 6/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.42 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | CDK7 | P50613 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CCNH | P51946 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | JAK3 | P52333 | 5/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | YES1 | P07947 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969931 | 0.88 | CCNT1 (0.45) | CDK9CCNT1CCNA2CDK2CDK7 | |
| SCHEMBL13881458 | 0.88 | SRC (0.53) | CDK9CCNT1CCNA2CDK2CDK7 | |
| SCHEMBL3968736 | 0.88 | JAK2 (0.44) | CDK9CCNT1CCNA2CDK2CDK7 | |
| SCHEMBL3968343 | 0.86 | JAK2 (0.52) | CDK9CDK7JAK2JAK3BRD4 | |
| SCHEMBL3965200 | 0.84 | AXL (0.41) | CDK1JAK2JAK3BRD4AXL | |
| SCHEMBL3966018 | 0.82 | CCNT1 (0.42) | CDK9CCNT1CCNA2CDK2CDK7 | |
| SCHEMBL3960896 | 0.82 | CCNA2 (0.46) | CDK9CCNT1CCNA2CDK2CDK7 | |
| SCHEMBL3969743 | 0.80 | AXL (0.42) | JAK2JAK3BRD4AXLYES1 | |
| SCHEMBL3968635 | 0.79 | AXL (0.39) | CDK1JAK2JAK3BRD4AXL | |
| SCHEMBL3966066 | 0.78 | AXL (0.41) | CDK9CDK7JAK2JAK3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |