Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13881619 | 0.85 | LMNA (0.58) | TAAR1TDP1TSHRMAPK1KDM4E | |
| SCHEMBL29818707 | 0.84 | MAPK1 (0.47) | TAAR1TDP1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL3964539 | 0.84 | TAAR1 (0.45) | TAAR1TDP1L3MBTL1TSHRMAPK1 | |
| SCHEMBL29819005 | 0.81 | TDP1 (0.53) | TAAR1TDP1L3MBTL1MAPK1LTA4H | |
| SCHEMBL2208810 | 0.81 | TDP1 (0.53) | TAAR1TDP1L3MBTL1MAPK1LTA4H | |
| SCHEMBL15150952 | 0.81 | TAAR1 (0.53) | TAAR1TDP1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL9107098 | 0.80 | TAAR1 (0.70) | TAAR1TSHRMAPK1KDM4ELTA4H | |
| SCHEMBL2206121 | 0.79 | TAAR1 (0.46) | TAAR1TSHRMAPK1KDM4ELMNA | |
| SCHEMBL19291732 | 0.79 | TAAR1 (0.46) | TAAR1TSHRMAPK1KDM4ELMNA | |
| SCHEMBL29818854 | 0.79 | TAAR1 (0.46) | TAAR1TSHRMAPK1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091955-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | Acucela, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009045479-A1 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT | ACUCELA INC. (US) | 2009-04-09 | — | — | WO | disclosed |