Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15956508 | 0.77 | HTR2C (0.44) | HTR2AHTR2CHTR2BSLC6A3TSHR | |
| SCHEMBL15955550 | 0.77 | TAAR1 (0.42) | TAAR1HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL11611974 | 0.77 | KDM1A (0.47) | HTR2AHTR2CHTR2BTSHRKDM1A | |
| SCHEMBL21280037 | 0.77 | TSHR (0.45) | HTR2AHTR2CHTR2BTSHRALDH1A1 | |
| SCHEMBL5434824 | 0.75 | MAPT (0.44) | TAAR1HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL24705 | 0.74 | KDM4E (0.44) | TAAR1HTR2CSLC6A3SLC6A2TSHR | |
| SCHEMBL9778896 | 0.74 | LMNA (0.47) | TAAR1MEN1KMT2A | |
| SCHEMBL11278907 | 0.74 | MAPT (0.47) | TAAR1HTR2AHTR2CHTR2BGID4 | |
| SCHEMBL9778874 | 0.73 | MAOB (0.56) | — | |
| SCHEMBL9778719 | 0.73 | NR4A2 (0.48) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3653609-B1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INST RES AGING (US) | 2024-04-03 | — | — | EP | disclosed |
| US-11091444-B2 | Hydantoins that modulate BACE-mediated app processing | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2021-08-17 | — | — | US | disclosed |
| US-11091444-B2 | Hydantoins that modulate BACE-mediated app processing | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2021-08-17 | — | — | US | disclosed |
| US-10766867-B2 | Hydantoins that modulate BACE-mediated APP processing | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2020-09-08 | — | — | US | disclosed |
| US-10766867-B2 | Hydantoins that modulate BACE-mediated APP processing | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2020-09-08 | — | — | US | disclosed |
| EP-3653609-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | Buck Institute for Research on Aging (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-3653609-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | Buck Institute for Research on Aging (US) | 2020-05-20 | — | — | EP | disclosed |
| US-20200148648-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING | 2020-05-14 | — | — | US | disclosed |
| US-20200148648-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING | 2020-05-14 | — | — | US | disclosed |
| EP-2956443-B1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INST RES AGING (US) | 2019-09-25 | — | — | EP | disclosed |
| EP-1383463-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS INC (US) | 2009-03-25 | — | — | EP | disclosed |
| US-7449490-B2 | Pharmaceutically active compounds and methods of use | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-7101905-B2 | Pharmaceutically active compounds and methods of use | KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC. (US) | 2006-09-05 | — | — | US | disclosed |
| US-20060183921-A1 | Pharmaceutically active compounds and methods of use | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. | 2006-08-17 | — | — | US | disclosed |
| EP-1383463-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | King Pharmaceuticals, Inc. (US) | 2004-01-28 | — | — | EP | disclosed |
| US-20030073733-A1 | Pharmaceutically active compounds and methods of use | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. | 2003-04-17 | — | — | US | disclosed |
| WO-2002083083-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS, INC. (US) | 2002-10-24 | — | — | WO | disclosed |
| US-4127588-A | Sulphur containing derivatives | HOFFMANN-LA ROCHE INC. (US) | 1978-11-28 | — | — | US | disclosed |
| US-4073797-A | CORONARY DILATOR | HOFFMANN-LA ROCHE INC. (US) | 1978-02-14 | — | — | US | disclosed |
| US-4003914-A | DITHIANE AND DISULFONE CORONARY DILATING AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183921-A1 | Pharmaceutically active compounds and methods of use | TRPV1, TPMT, ACHE | TAAR1 2871/4885HTR2A 934/4885HTR2C 386/4885 |
| US-11091444-B2 | Hydantoins that modulate BACE-mediated app processing | BACE1, APP, BACE2 | TAAR1 1835/4885HTR2A 383/4885HTR2C 605/4885 |
| US-20030073733-A1 | Pharmaceutically active compounds and methods of use | TRPV1, TPMT, ACHE | TAAR1 2871/4885HTR2A 934/4885HTR2C 386/4885 |
| US-20200148648-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BACE1, APP, BACE2 | TAAR1 1835/4885HTR2A 383/4885HTR2C 605/4885 |
| US-10766867-B2 | Hydantoins that modulate BACE-mediated APP processing | BACE1, APP, BACE2 | TAAR1 1835/4885HTR2A 383/4885HTR2C 605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.