Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27975334 | 0.87 | MAPT (0.71) | MAPTLMNAKDM4EALDH1A1TP53 | |
| SCHEMBL29817530 | 0.85 | MAPT (1.00) | MAPTLMNAKDM4EALDH1A1TP53 | |
| SCHEMBL27893270 | 0.85 | MAPT (1.00) | MAPTLMNAKDM4EALDH1A1TP53 | |
| SCHEMBL29817685 | 0.84 | KMT2A (0.56) | MAPTLMNAKDM4EALDH1A1TP53 | |
| SCHEMBL27168680 | 0.84 | KMT2A (0.56) | MAPTLMNAKDM4EALDH1A1TP53 | |
| SCHEMBL28061972 | 0.83 | HDAC1 (0.71) | MAPTLMNAKDM4EALDH1A1TP53 | |
| SCHEMBL26943206 | 0.83 | STAT3 (0.63) | MAPTLMNAKDM4EALDH1A1TP53 | |
| SCHEMBL28567710 | 0.82 | KMT2A (0.58) | MAPTLMNAKDM4EALDH1A1TP53 | |
| SCHEMBL2216825 | 0.82 | MAPT (0.77) | MAPTLMNAKDM4EALDH1A1TP53 | |
| SCHEMBL28678168 | 0.82 | MAPT (0.52) | MAPTLMNAKDM4EALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102952207-B | Preparation method and application of 6-(1-methyl-beta-carboline-3-carboxylic acetyl)-6-deoxy-beta-cyclodextrin and supramolecular inclusion complex thereof with adriamycin | UNIV CAPITAL MEDICAL | 2014-12-03 | — | — | CN | claimed |
| CN-103539837-A | 1-methyl-beta-carbolinyl-3-formyl RGD peptides, and synthesis, nano structure, antithrombotic action and application thereof | PENG LI | 2014-01-29 | — | — | CN | claimed |
| CN-103539835-A | 1-methyl-tetrahydro-beta-carbolinyl-3-formyl YIGS peptides, and synthesis, nano structure, antithrombotic action and application thereof | PENG LI | 2014-01-29 | — | — | CN | claimed |
| CN-103450338-A | Heterocyclic carboxylic acid-modified thymopentins and their preparation method, anti-tumor effect and use | UNIV CAPITAL MEDICAL SCIENCES | 2013-12-18 | — | — | CN | claimed |
| CN-102952207-A | Preparation method and application of 6-(1-methyl-beta-carboline-3-carboxylic acetyl)-6-deoxy-beta-cyclodextrin and supramolecular inclusion complex thereof with adriamycin | UNIV CAPITAL MEDICAL | 2013-03-06 | — | — | CN | claimed |
| CN-116789870-A | Preparation and application of 6- (1-methyl-beta-carboline-3-carboxylic acid acetyl) -6-deoxy-beta-cyclodextrin and resveratrol inclusion compound thereof | 首都医科大学 | 2023-09-22 | — | — | CN | disclosed |
| CN-116789870-A | Preparation and application of 6- (1-methyl-beta-carboline-3-carboxylic acid acetyl) -6-deoxy-beta-cyclodextrin and resveratrol inclusion compound thereof | 首都医科大学 | 2023-09-22 | — | — | CN | disclosed |
| CN-116789870-A | Preparation and application of 6- (1-methyl-beta-carboline-3-carboxylic acid acetyl) -6-deoxy-beta-cyclodextrin and resveratrol inclusion compound thereof | 首都医科大学 | 2023-09-22 | — | — | CN | disclosed |
| CN-111303148-B | 1-substituted beta-carboline derivatives and application thereof | 南京农业大学 | 2022-08-30 | — | — | CN | disclosed |
| EP-3459950-B1 | TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, AS FUNGICIDES AND INSECTICIDES | JINGBO AGROCHEMICALS TECH CO LTD (CN) | 2022-05-18 | — | — | EP | disclosed |
| EP-3459951-B1 | TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, AS FUNGICIDES AND INSECTICIDES | JINGBO AGROCHEMICALS TECH CO LTD (CN) | 2022-05-11 | — | — | EP | disclosed |
| CN-109134460-B | Synthesis method of beta-carboline compound | 南开大学 | 2021-04-06 | — | — | CN | disclosed |
| CN-1743327-A | Indole alkaloid derivative, and its preparing method and use | CAPITAL MEDICAL UNIV (CN) | 2006-03-08 | — | — | CN | disclosed |
| WO-2005092335-A1 | TETRAHYDRO-β-CARBOLINE COMPOUNDS AND USE THEREOF | MEDIQUEST THERAPEUTICS, INC. (US) | 2005-10-06 | — | — | WO | disclosed |
| US-20050209264-A1 | Tetrahydro-beta-carboline compounds and use thereof | MEDIQUEST THERAPEUTICS, INC. (US) | 2005-09-22 | — | — | US | disclosed |
| CN-1594358-A | Treatment of tumors by administration of growth hormone releasing compounds or antagonists thereof | ARDANA BIOSCIENCE LTD (DE) | 2005-03-16 | — | — | CN | disclosed |
| EP-0556008-B1 | Condensed imidazopyridine derivatives with psychotropic activity | SHIONOGI & CO (JP) | 1997-05-14 | — | — | EP | disclosed |
| US-5461062-A | Psychotropic agent as antianxiety agent, anesthesia antagonistic agent | SHIONOGI & CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5378848-A | Benzodiazepine agonist, psychotropic, antianxiety, cerebral function activator, anesthesia atagonist | SHIONOGI & CO., LTD. (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0556008-A1 | Condensed imidazopyridine derivatives with psychotropic activity | SHIONOGI & CO., LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209264-A1 | Tetrahydro-beta-carboline compounds and use thereof | BACE1, SNCA, PARK7 | MAPT 335/4885LMNA 1798/4885KDM4E 1489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.