Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971882 | 0.90 | PTGDR2 (0.46) | PTGDR2PTGDR | |
| SCHEMBL3967751 | 0.88 | PTGDR2 (0.39) | PTGDR2MEN1KMT2ASMN1; SMN2PTGS2 | |
| SCHEMBL3962109 | 0.87 | PTGDR2 (0.39) | PTGDR2MEN1KMT2APTGS2GAA | |
| SCHEMBL3969463 | 0.86 | PTGDR2 (0.47) | PTGDR2MEN1KMT2APTGS2MAPT | |
| SCHEMBL3962084 | 0.85 | PTGDR2 (0.39) | PTGDR2MEN1KMT2APTGS2GAA | |
| SCHEMBL3968970 | 0.84 | PTGDR2 (0.46) | PTGDR2MEN1KMT2APTGS2GAA | |
| SCHEMBL3968252 | 0.82 | PTGDR2 (0.38) | PTGDR2MEN1KMT2APTGS2GAA | |
| SCHEMBL3972653 | 0.82 | PTGDR2 (0.42) | PTGDR2MEN1KMT2APTGS2GAA | |
| SCHEMBL3962099 | 0.81 | PTGDR2 (0.40) | PTGDR2PTGS2GAAMAPTNPSR1 | |
| SCHEMBL3970488 | 0.80 | SMN1; SMN2 (0.32) | MEN1KMT2ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |