Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967115 | 0.91 | PTGDR2 (0.48) | PTGDR2HTR6GPR27 | |
| SCHEMBL3965620 | 0.86 | PTGDR2 (0.54) | PTGDR2HTR6 | |
| SCHEMBL3968252 | 0.86 | PTGDR2 (0.38) | PTGDR2GAANPSR1MAPTPTGS1 | |
| SCHEMBL3969463 | 0.85 | PTGDR2 (0.47) | PTGDR2MAPTPTGS2 | |
| SCHEMBL3962084 | 0.83 | PTGDR2 (0.39) | PTGDR2GAANPSR1HTR6PTGS1 | |
| SCHEMBL3962109 | 0.83 | PTGDR2 (0.39) | PTGDR2GAANPSR1MAPTPTGS2 | |
| SCHEMBL3968018 | 0.81 | PTGDR2 (0.39) | PTGDR2GAANPSR1MAPTPTGS2 | |
| SCHEMBL3968970 | 0.81 | PTGDR2 (0.46) | PTGDR2GAANPSR1MAPTPTGS2 | |
| SCHEMBL3972653 | 0.80 | PTGDR2 (0.42) | PTGDR2GAAMAPTPTGS2 | |
| SCHEMBL3968672 | 0.78 | PTGDR2 (0.40) | PTGDR2AKR1C3AKR1C2MAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |