Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 5/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.37 |
| ▸ | S100A10 | P60903 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7202277 | 0.83 | MEN1 (0.46) | MAOAMAOBBCL2MCL1HTR2C | |
| SCHEMBL7542850 | 0.79 | BCL2 (0.50) | MAOAMAOBBCL2MCL1ERN1 | |
| SCHEMBL25466533 | 0.77 | LMNA (0.40) | MAOAMAOBBCL2MCL1HTR2C | |
| SCHEMBL585573 | 0.77 | MAOA (0.47) | MAOAMAOBBCL2MCL1HTR2C | |
| SCHEMBL7535912 | 0.76 | ALDH1A1 (0.43) | MAOAMAOBBCL2MCL1ERN1 | |
| SCHEMBL7493216 | 0.76 | ALDH1A1 (0.47) | MCL1ERN1ALDH1A1HPGD | |
| SCHEMBL15697534 | 0.73 | ALDH1A1 (0.39) | ERN1ALDH1A1LMNATDP1 | |
| SCHEMBL1125758 | 0.72 | ERN1 (0.50) | ERN1ALDH1A1MEN1KMT2A | |
| SCHEMBL1465547 | 0.71 | ERN1 (0.47) | ERN1ALDH1A1MEN1LMNATHRB | |
| SCHEMBL3848297 | 0.71 | KMT2A (0.44) | ALDH1A1HPGDMEN1LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |