Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.36 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.35 |
| ▸ | CDK9 | P50750 | 8/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.35 |
| ▸ | CDK7 | P50613 | 5/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | CCNH | P51946 | 4/20 | 0.35 |
| ▸ | CDK1 | P06493 | 3/20 | 0.35 |
| ▸ | CDK4 | P11802 | 3/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.35 |
| ▸ | CCND1 | P24385 | 3/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.35 |
| ▸ | CDK3 | Q00526 | 3/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.35 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.34 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL47770 | 0.91 | PDE10A (0.49) | PDE10AMAPKAPK2KCNN3CDK9CCNT1 | |
| SCHEMBL10209999 | 0.88 | PDE10A (0.53) | PDE10AMAPKAPK2KCNN3CDK9CCNT1 | |
| SCHEMBL10210928 | 0.87 | PDE10A (0.49) | PDE10AMAPKAPK2KCNN3CDK9CCNT1 | |
| SCHEMBL20682 | 0.80 | PDE10A (0.34) | PDE10ACDK9CDK7CDK2CCNA2 | |
| SCHEMBL19818 | 0.78 | PDE10A (0.41) | PDE10AMAPKAPK2KCNN3CDK9CCNT1 | |
| SCHEMBL45705 | 0.78 | KCNN3 (0.57) | PDE10AKCNN3KCNN1KCNN2 | |
| SCHEMBL7879251 | 0.75 | KCNN3 (0.38) | PDE10AMAPKAPK2KCNN3CDK2KCNN1 | |
| SCHEMBL7887263 | 0.75 | PDE10A (0.41) | PDE10AMAPKAPK2KCNN3CDK9CCNT1 | |
| SCHEMBL2679823 | 0.75 | CRHR1 (0.32) | PDE10ACDK2CCNA2CCNA1 | |
| SCHEMBL7874462 | 0.74 | CCNT1 (0.43) | CDK9CCNT1CDK7CDK2CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |