Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.41 |
| ▸ | KCNN3 | Q9UGI6 | 8/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.37 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45705 | 0.82 | KCNN3 (0.57) | PDE10AKCNN3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7879251 | 0.79 | KCNN3 (0.38) | PDE10AKCNN3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL30183 | 0.78 | CRHR1 (0.33) | PRKAA1CDK2CCNE1CCNT1CDK9 | |
| SCHEMBL7874462 | 0.78 | CCNT1 (0.43) | CDK2CCNE1CCNT1CDK9CCNA1 | |
| SCHEMBL10209999 | 0.75 | PDE10A (0.53) | PDE10AKCNN3KCNN1KCNN2CDK2 | |
| SCHEMBL39693 | 0.75 | PDE10A (0.50) | PDE10AKCNN3KCNN1KCNN2CDK2 | |
| SCHEMBL47770 | 0.74 | PDE10A (0.49) | PDE10AKCNN3KCNN1KCNN2CDK2 | |
| SCHEMBL10210928 | 0.74 | PDE10A (0.49) | PDE10AKCNN3KCNN1KCNN2CDK2 | |
| SCHEMBL19818 | 0.70 | PDE10A (0.41) | PDE10AKCNN3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL901809 | 0.68 | GSK3B (0.52) | PDE10AKCNN3KCNN1KCNN2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |