Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | CRHBP | P24387 | 1/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969682 | 1.00 | MAPK1 (0.61) | MAPK1HTTALDH1A1MAPTL3MBTL1 | |
| SCHEMBL11694394 | 0.75 | SMN1; SMN2 (0.50) | MAPK1HTTALDH1A1MAPTL3MBTL1 | |
| SCHEMBL11694397 | 0.75 | SMN1; SMN2 (0.50) | MAPK1HTTALDH1A1MAPTL3MBTL1 | |
| SCHEMBL11696539 | 0.70 | RAB9A (0.51) | MAPK1ALDH1A1MAPTL3MBTL1CRHBP | |
| SCHEMBL11696537 | 0.70 | RAB9A (0.51) | MAPK1ALDH1A1MAPTL3MBTL1CRHBP | |
| SCHEMBL1427483 | 0.69 | SMN1; SMN2 (0.73) | MAPK1HTTALDH1A1MAPTL3MBTL1 | |
| SCHEMBL1427482 | 0.69 | SMN1; SMN2 (0.73) | MAPK1HTTALDH1A1MAPTL3MBTL1 | |
| SCHEMBL11676244 | 0.69 | MAPT (0.64) | MAPK1ALDH1A1MAPTL3MBTL1RAB9A | |
| SCHEMBL11676241 | 0.69 | MAPT (0.64) | MAPK1ALDH1A1MAPTL3MBTL1RAB9A | |
| SCHEMBL16921257 | 0.68 | ALDH1A1 (1.00) | MAPK1HTTALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016061-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | Glaxo Group Limited (GB) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007122241-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-11-01 | — | — | WO | disclosed |