Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
| ▸ | FASN | P49327 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970823 | 0.80 | MAPT (0.36) | KDM4ECYP2C19HSD11B1 | |
| SCHEMBL3977568 | 0.78 | HSD11B1 (0.33) | HSD11B1 | |
| SCHEMBL3970810 | 0.77 | AKT1 (0.32) | HSD11B1 | |
| SCHEMBL2977992 | 0.77 | PDK2 (0.38) | KDM4EHSD11B1 | |
| SCHEMBL3095009 | 0.76 | NAMPT (0.39) | HSD11B1 | |
| SCHEMBL3101115 | 0.76 | MAPT (0.40) | KDM4E | |
| SCHEMBL2973860 | 0.76 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL3972108 | 0.74 | HSD11B1 (0.33) | KDM4EHSD11B1 | |
| SCHEMBL3907137 | 0.74 | PDE2A (0.32) | — | |
| SCHEMBL3974626 | 0.74 | HSD11B1 (0.33) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |