Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972826 | 0.90 | NAMPT (0.36) | NAMPTHSD11B1 | |
| SCHEMBL3975472 | 0.80 | HSD11B1 (0.45) | NAMPTHSD11B1 | |
| SCHEMBL3977568 | 0.79 | HSD11B1 (0.33) | HSD11B1SMN1; SMN2 | |
| SCHEMBL3970810 | 0.78 | AKT1 (0.32) | HSD11B1ALDH1A1 | |
| SCHEMBL2977992 | 0.78 | PDK2 (0.38) | HSD11B1 | |
| SCHEMBL3978009 | 0.77 | ELOVL1 (0.33) | HSD11B1 | |
| SCHEMBL3972514 | 0.77 | MGLL (0.33) | HSD11B1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2973860 | 0.77 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL3970823 | 0.77 | MAPT (0.36) | NAMPTHSD11B1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3970072 | 0.76 | KDM4E (0.34) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256114-A1 | Amido Compounds And Their Use As Pharmaceuticals | INCYTE CORPORATION (US) | 2010-10-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256114-A1 | Amido Compounds And Their Use As Pharmaceuticals | HSD11B1, CYP11B1, HSD11B2 | NAMPT 1291/4885HSD11B1 1/4885CCR1 3003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.