Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.46 |
| ▸ | YES1 | P07947 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | AIMP2 | Q13155 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883571 | 0.91 | SRC (0.46) | SRCYES1PDGFRBJAK2BRD4 | |
| SCHEMBL3971227 | 0.85 | TTK (0.44) | SRCYES1PDGFRBPRKCQ | |
| SCHEMBL3975392 | 0.84 | PDPK1 (0.43) | PDPK1JAK2JAK3ALDH1A1SMN1; SMN2 | |
| SCHEMBL4082415 | 0.84 | TTK (0.46) | SRCPRKCQJAK2JAK3 | |
| SCHEMBL3969173 | 0.79 | TTK (0.40) | PDPK1JAK2JAK3L3MBTL1 | |
| SCHEMBL3971647 | 0.79 | PDPK1 (0.47) | PDPK1PRKCQJAK2BRD4JAK3 | |
| SCHEMBL3970201 | 0.78 | MAPK1 (0.41) | PDPK1JAK2JAK3L3MBTL1 | |
| SCHEMBL3967492 | 0.78 | MAPK1 (0.41) | PDPK1JAK2JAK3L3MBTL1 | |
| SCHEMBL3969268 | 0.78 | HRH3 (0.46) | SRCPDPK1LTA4HJAK2JAK3 | |
| SCHEMBL13883580 | 0.78 | AXL (0.46) | SRCYES1PDGFRBJAK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |