Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.71 |
| ▸ | TP53 | P04637 | 5/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.71 |
| ▸ | CCR1 | P32246 | 3/20 | 0.71 |
| ▸ | CCR5 | P51681 | 3/20 | 0.71 |
| ▸ | CCR8 | P51685 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | ALPL | P05186 | 2/20 | 0.71 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.71 |
| ▸ | ALPI | P09923 | 1/20 | 0.71 |
| ▸ | ALPG | P10696 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | METAP1 | P53582 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30172832 | 0.84 | KDM4E (1.00) | KDM4ETP53SMN1; SMN2ALOX15L3MBTL1 | |
| SCHEMBL7964803 | 0.84 | KDM4E (1.00) | KDM4ETP53SMN1; SMN2ALOX15L3MBTL1 | |
| Terpyridine SCHEMBL29357603 | 0.84 | KDM4E (1.00) | KDM4ETP53SMN1; SMN2ALOX15L3MBTL1 | |
| Terpyridine SCHEMBL57442 | 0.84 | KDM4E (1.00) | KDM4ETP53SMN1; SMN2ALOX15L3MBTL1 | |
| Terpyridine SCHEMBL1616654 | 0.81 | KDM4E (0.95) | KDM4ETP53SMN1; SMN2ALOX15L3MBTL1 | |
| Terpyridine SCHEMBL2953496 | 0.81 | KDM4E (0.95) | KDM4ETP53SMN1; SMN2ALOX15L3MBTL1 | |
| Terpyridine SCHEMBL3150051 | 0.81 | KDM4E (0.95) | KDM4ETP53SMN1; SMN2ALOX15L3MBTL1 | |
| Terpyridine SCHEMBL7112915 | 0.81 | KDM4E (0.95) | KDM4ETP53SMN1; SMN2ALOX15L3MBTL1 | |
| Terpyridine SCHEMBL5899140 | 0.81 | KDM4E (0.95) | KDM4ETP53SMN1; SMN2ALOX15L3MBTL1 | |
| Terpyridine SCHEMBL8536195 | 0.81 | KDM4E (0.95) | KDM4ETP53SMN1; SMN2ALOX15L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119717-B1 | 8-[3-amino-piperidin-1-yl]-xanthins, their production and utilisation as DPP IV inhibitors | BOEHRINGER INGELHEIM INT (DE) | 2018-01-17 | — | — | EP | claimed |
| US-8697868-B2 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-04-15 | — | — | US | claimed |
| US-20090137801-A1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-28 | — | — | US | claimed |
| EP-1758905-B1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINE, THE PRODUCTION THEREOF AND THE USE IN THE FORM OF A DDP-IV INHIBITOR | BOEHRINGER INGELHEIM INT (DE) | 2009-04-29 | — | — | EP | claimed |
| US-7501426-B2 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-10 | — | — | US | claimed |
| US-20050234108-A1 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-20 | — | — | US | claimed |
| US-8865914-B2 | Fluorescent probes for detection of copper | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-10-21 | — | — | US | disclosed |
| US-8697868-B2 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-04-15 | — | — | US | disclosed |
| US-20140051863-A1 | FLUORESCENT PROBES FOR DETECTION OF COPPER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2014-02-20 | — | — | US | disclosed |
| EP-2119717-A1 | 8-[3-amino-piperidin-1-yl]-xanthins, their production and utilisation as DPP IV inhibitors | Boehringer Ingelheim International GmbH (DE) | 2009-11-18 | — | — | EP | disclosed |
| US-20090137801-A1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-28 | — | — | US | disclosed |
| US-7501426-B2 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-10 | — | — | US | disclosed |
| CN-1238338-C | Process for the preparation of 4(5)-amino-5(4)carboxamidoimidoimidazoles and intermediates thereof | NIPPON SODA CO (JP) | 2006-01-25 | — | — | CN | disclosed |
| US-20050234108-A1 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-20 | — | — | US | disclosed |
| US-6797828-B1 | Processes for the preparation of 4(5)-amino-5(4)-carboxamidoimidazoles and intermediates thereof | NIPPON SODA CO. LTD. (JP) | 2004-09-28 | — | — | US | disclosed |
| CN-1502604-A | Process for the preparation of 4(5)-amino-5(4)carboxamidoimidoimidazoles and intermediates thereof | �ձ�������ʽ���� | 2004-06-09 | — | — | CN | disclosed |
| CN-1150169-C | Process for the preparation of 4(5) -amino-5 (4) -carbamoylimidazoles and intermediates thereof | �ձ�������ʽ���� | 2004-05-19 | — | — | CN | disclosed |
| CN-1374951-A | Process for the preparation of 4(5) -amino-5 (4) -carbamoylimidazoles and intermediates thereof | NIPPON SODA CO (JP) | 2002-10-16 | — | — | CN | disclosed |
| EP-1215206-A1 | PROCESSES FOR THE PREPARATION OF 4(5)-AMINO-5(4)-CARBOXAMIDOIMIDAZOLES AND INTERMEDIATES THEREOF | NIPPON SODA CO., LTD. (JP) | 2002-06-19 | — | — | EP | disclosed |
| EP-0499501-B1 | New macrocyclic nitrogen ligands, method for their preparation, metal complexes, diagnostic and therapeutic compositions | GUERBET SA (FR) | 1998-08-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051863-A1 | FLUORESCENT PROBES FOR DETECTION OF COPPER | NCS1, CHERP, RYR1 | KDM4E 4092/4885TP53 1630/4885SMN1; SMN2 3450/4885 |
| US-20090137801-A1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | DPP8, DPP4, DPP7 | KDM4E 1036/4885TP53 4866/4885SMN1; SMN2 2069/4885 |
| US-20050234108-A1 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions | DPP8, DPP4, DPP7 | KDM4E 1140/4885TP53 4859/4885SMN1; SMN2 1725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.