Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | PRNP | P04156 | 1/20 | 0.65 |
| ▸ | PPARG | P37231 | 1/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.65 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | DHODH | Q02127 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 4/20 | 0.47 |
| ▸ | FABP3 | P05413 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | PTGFR | P43088 | 5/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970605 | 0.91 | PRNP (0.79) | ALDH1A1PRNPPPARGRXFP1NR2E3 | |
| SCHEMBL2822472 | 0.88 | ALDH1A1 (1.00) | ALDH1A1PRNPPPARGRXFP1NR2E3 | |
| SCHEMBL13881528 | 0.88 | ALDH1A1 (0.60) | ALDH1A1PRNPPPARGRXFP1NR2E3 | |
| SCHEMBL2824330 | 0.87 | PRNP (0.61) | ALDH1A1PRNPPPARGRXFP1NR2E3 | |
| SCHEMBL13881531 | 0.86 | RXFP1 (0.60) | ALDH1A1PRNPPPARGRXFP1NR2E3 | |
| SCHEMBL2821075 | 0.85 | PRNP (0.59) | ALDH1A1PRNPPPARGRXFP1NR2E3 | |
| SCHEMBL3964820 | 0.84 | PRNP (0.58) | ALDH1A1PRNPPPARGRXFP1NR2E3 | |
| SCHEMBL3966576 | 0.82 | PRNP (0.56) | ALDH1A1PRNPPPARGRXFP1NR2E3 | |
| SCHEMBL31442477 | 0.79 | ALDH1A1 (0.74) | ALDH1A1PRNPPPARGRXFP1NR2E3 | |
| SCHEMBL31442647 | 0.78 | ALDH1A1 (0.76) | ALDH1A1PRNPPPARGRXFP1NR2E3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009041904-A1 | QUINOLINE COMPOUNDS HAVING AN ACTIVITY AGAINST THE GABAB RECEPTOR | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | WO | disclosed |
| WO-2009041904-A1 | QUINOLINE COMPOUNDS HAVING AN ACTIVITY AGAINST THE GABAB RECEPTOR | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | WO | disclosed |
| US-20090088441-A1 | Quinoline Compounds | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | US | disclosed |
| US-20090088441-A1 | Quinoline Compounds | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | US | disclosed |
| US-20090088441-A1 | Quinoline Compounds | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088441-A1 | Quinoline Compounds | GABRB1, HRH2, GABRA5 | ALDH1A1 2256/4885PRNP 3104/4885PPARG 615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.