Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.37 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.37 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774139 | 0.81 | ALDH1A1 (0.45) | RAB9ASMN1; SMN2NPC1KMT2APOLB | |
| SCHEMBL21172111 | 0.78 | DHODH (0.37) | CYP19A1 | |
| SCHEMBL3173623 | 0.74 | SMN1; SMN2 (0.46) | RAB9ASMN1; SMN2NPC1KMT2APOLB | |
| SCHEMBL3546257 | 0.72 | RAB9A (0.38) | RAB9ASMN1; SMN2NPC1KMT2APOLB | |
| SCHEMBL3970959 | 0.71 | CYP19A1 (0.36) | RAB9ASMN1; SMN2NPC1KMT2APOLB | |
| SCHEMBL19568986 | 0.70 | TDO2 (0.52) | RAB9ASMN1; SMN2NPC1KMT2AKDM4E | |
| SCHEMBL14564448 | 0.70 | ALDH1A1 (0.56) | RAB9ASMN1; SMN2NPC1KMT2APOLB | |
| SCHEMBL2517257 | 0.70 | — | — | |
| SCHEMBL11379135 | 0.68 | SLC22A12 (0.46) | RAB9ASMN1; SMN2NPC1KMT2AKDM4E | |
| SCHEMBL5774887 | 0.68 | CYP19A1 (0.40) | RAB9ASMN1; SMN2NPC1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051977-A2 | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1 | Amgen Inc. (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008011453-A2 | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLβ-HSD-1 | AMGEN INC. (US) | 2008-01-24 | — | — | WO | disclosed |