Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968520 | 0.80 | NISCH (0.39) | CDK2AXLJAK2TP53GAA | |
| SCHEMBL13881457 | 0.80 | JAK2 (0.44) | AXLJAK2TP53GAASMN1; SMN2 | |
| SCHEMBL4079587 | 0.78 | JAK2 (0.54) | CDK2JAK2 | |
| SCHEMBL13881491 | 0.78 | AXL (0.44) | AXLJAK2TP53GAAKDR | |
| SCHEMBL13881583 | 0.77 | AXL (0.54) | AXLJAK2KDR | |
| SCHEMBL3971237 | 0.76 | AXL (0.53) | AURKACDK2AXLJAK2KDR | |
| SCHEMBL3966844 | 0.75 | AXL (0.47) | CDK2AXLJAK2 | |
| SCHEMBL3969938 | 0.75 | AXL (0.56) | AURKAAXLJAK2KDR | |
| SCHEMBL1288588 | 0.70 | NISCH (0.55) | NISCH | |
| SCHEMBL13524678 | 0.70 | ADRA2A (0.44) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |