Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 10/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL350865 | 0.84 | ADAM17 (0.36) | — | |
| SCHEMBL3969701 | 0.83 | RORC (0.36) | FFAR1 | |
| SCHEMBL3975332 | 0.82 | MAOB (0.36) | — | |
| SCHEMBL3972419 | 0.81 | NR4A2 (0.39) | ALOX5APALOX5 | |
| SCHEMBL3907137 | 0.80 | PDE2A (0.32) | — | |
| SCHEMBL3970810 | 0.79 | AKT1 (0.32) | — | |
| SCHEMBL3968068 | 0.78 | CTSC (0.35) | — | |
| SCHEMBL2973860 | 0.77 | HSD11B1 (0.31) | — | |
| SCHEMBL3977568 | 0.76 | HSD11B1 (0.33) | — | |
| SCHEMBL3974626 | 0.75 | HSD11B1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |