Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | PRKCI | P41743 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972116 | 0.83 | ADORA2A (0.47) | ADORA2AADORA1KDM5BJAK2ROCK1 | |
| SCHEMBL3973616 | 0.78 | ADORA2A (0.44) | ADORA2AADORA1PDK1AXLPRKCI | |
| SCHEMBL3975335 | 0.76 | CYP2A6 (0.38) | ADORA2AADORA1PDK1AXLPRKCI | |
| SCHEMBL3967588 | 0.71 | PGK1 (0.38) | ADORA2AADORA1PDK1JAK2JAK3 | |
| SCHEMBL12347998 | 0.71 | AXL (0.47) | AXLPRKCIJAK2JAK1ROCK1 | |
| SCHEMBL3969173 | 0.71 | TTK (0.40) | AXLJAK2JAK1ROCK1AURKA | |
| SCHEMBL13883465 | 0.71 | JAK1 (0.40) | JAK2JAK1ROCK1AURKADAPK3 | |
| SCHEMBL13883624 | 0.71 | JAK1 (0.40) | MAPTJAK2JAK1ROCK1AURKA | |
| SCHEMBL3967492 | 0.70 | MAPK1 (0.41) | AXLJAK2JAK1ROCK1AURKA | |
| SCHEMBL4258828 | 0.70 | JAK1 (0.43) | ADORA2AMAPTJAK1DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |