Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | PRKCI | P41743 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975493 | 0.81 | MEN1 (0.38) | ADORA2AADORA1AXLPRKCIPDK1 | |
| SCHEMBL3971472 | 0.78 | ADORA2A (0.38) | ADORA2AADORA1AXLPRKCIJAK2 | |
| SCHEMBL4081014 | 0.78 | IKBKB (0.43) | ADORA2AADORA1JAK2JAK1PDK1 | |
| SCHEMBL3975335 | 0.77 | CYP2A6 (0.38) | ADORA2AADORA1AXLPRKCIPDK1 | |
| SCHEMBL3967588 | 0.74 | PGK1 (0.38) | ADORA2AADORA1JAK2PDK1IKBKB | |
| SCHEMBL12574854 | 0.73 | PRKCI (0.46) | ADORA2AADORA1AXLPRKCIJAK2 | |
| SCHEMBL31735867 | 0.73 | JAK2 (0.47) | ADORA2AADORA1AXLPRKCIJAK2 | |
| SCHEMBL13213033 | 0.71 | JAK2 (0.56) | ADORA2AADORA1AXLJAK2JAK1 | |
| SCHEMBL10125092 | 0.70 | PRKCI (0.51) | ADORA2AADORA1AXLPRKCIJAK2 | |
| SCHEMBL691603 | 0.69 | PRKCI (0.44) | ADORA2AADORA1AXLPRKCIJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |