Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | DHPS | P49366 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975335 | 0.83 | CYP2A6 (0.38) | PDK1ADORA2AADORA1CYP2A6 | |
| SCHEMBL28596883 | 0.75 | CLK1 (0.47) | APPDHPSPRKCQPRKCDMAPKAPK2 | |
| SCHEMBL30173282 | 0.75 | CLK1 (0.47) | APPDHPSPRKCQPRKCDMAPKAPK2 | |
| SCHEMBL3973616 | 0.74 | ADORA2A (0.44) | PDK1JAK2JAK3ADORA2AADORA1 | |
| SCHEMBL10125408 | 0.74 | CCNK (0.44) | PGK1APPDHPSPRKCQPRKCD | |
| SCHEMBL13213033 | 0.73 | JAK2 (0.56) | PDK1PRKCQJAK2JAK3ADORA2A | |
| SCHEMBL101422 | 0.71 | CDK9 (0.54) | PRKCQJAK2JAK3CCNT1CCNA2 | |
| SCHEMBL3971472 | 0.71 | ADORA2A (0.38) | PDK1PRKCQJAK2JAK3ADORA2A | |
| SCHEMBL3975493 | 0.71 | MEN1 (0.38) | PDK1ADORA2AADORA1CYP2A6 | |
| SCHEMBL3975437 | 0.71 | CDK1 (0.42) | PRKCQPRKCDIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |