Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 5/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 5/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.32 |
| ▸ | PAK4 | O96013 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | LTK | P29376 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4407227 | 0.91 | JAK1 (0.38) | JAK1SYKPIK3CAPIK3CGPTK2 | |
| SCHEMBL13883626 | 0.89 | IKBKB (0.41) | JAK1SYKJAK2SRCAURKA | |
| SCHEMBL13883718 | 0.83 | AXL (0.38) | JAK1JAK2TNIK | |
| SCHEMBL3971650 | 0.81 | TNIK (0.39) | JAK1SYKAGTR2PTK2JAK2 | |
| SCHEMBL4085714 | 0.80 | JAK1 (0.38) | JAK1SYKAGTR2PTK2JAK2 | |
| SCHEMBL13883627 | 0.79 | JAK2 (0.37) | JAK1AGTR2PTK2JAK2HDAC1 | |
| SCHEMBL13883576 | 0.77 | JAK2 (0.40) | JAK1PTK2JAK2ABL1AURKA | |
| SCHEMBL4077575 | 0.77 | JAK2 (0.43) | JAK1PTK2JAK2ABL1AURKA | |
| SCHEMBL4255795 | 0.76 | JAK1 (0.38) | JAK1SYKPTK2JAK2HDAC1 | |
| SCHEMBL4081376 | 0.75 | JAK2 (0.40) | JAK1PTK2JAK2ABL1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | claimed |