Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978586 | 0.90 | PROKR1 (0.41) | SLC6A2SLC6A4SLC6A3SSTR5PROKR1 | |
| SCHEMBL3972445 | 0.88 | SSTR5 (0.40) | SLC6A2SLC6A4SLC6A3SSTR5PROKR1 | |
| SCHEMBL3971901 | 0.87 | SSTR5 (0.43) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL3973243 | 0.83 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2TACR1 | |
| SCHEMBL4703982 | 0.81 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL3973033 | 0.81 | SSTR5 (0.42) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL4705064 | 0.79 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL3977612 | 0.78 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL3972925 | 0.78 | MAPK1 (0.44) | SLC6A2SLC6A4SLC6A3KCNH2MAPK1 | |
| SCHEMBL3974287 | 0.78 | IRAK4 (0.42) | SLC6A2SLC6A4SLC6A3IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |