Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | MC5R | P33032 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
| ▸ | MBTPS1 | Q14703 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977361 | 0.93 | REN (0.47) | MAPK1RENSMN1; SMN2NPSR1SLC6A2 | |
| SCHEMBL3973856 | 0.93 | L3MBTL1 (0.47) | RENL3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3973369 | 0.92 | REN (0.43) | MAPK1RENL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3978538 | 0.91 | REN (0.43) | RENNPSR1SLC6A2SLC6A4FLT4 | |
| SCHEMBL3974286 | 0.91 | REN (0.43) | RENL3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3977612 | 0.91 | SLC6A2 (0.37) | MAPK1RENALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL3971901 | 0.91 | SSTR5 (0.43) | MAPK1RENMBTPS1SLC6A2SLC6A4 | |
| SCHEMBL3973812 | 0.90 | SSTR5 (0.38) | MBTPS1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3972873 | 0.90 | SLC6A9 (0.37) | MAPK1RENSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3971524 | 0.89 | MAPK1 (0.36) | MAPK1RENSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |