SCHEMBL3980322

SCHEMBL3980322

Cc1cc(C(N)=O)c(NCCC2CC2)cc1C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 6/20 0.40
HSP90AB1 P08238 6/20 0.40
PIM1 P11309 1/20 0.40
PIM2 Q9P1W9 1/20 0.40
LIPC P11150 1/20 0.37
LIPG Q9Y5X9 1/20 0.37
JAK1 P23458 2/20 0.36
JAK3 P52333 2/20 0.36
JAK2 O60674 1/20 0.36
NOTUM Q6P988 1/20 0.36
CD38 P28907 1/20 0.35
CYP2C9 P11712 1/20 0.35
OPRL1 P41146 3/20 0.34
KDM4C Q9H3R0 1/20 0.34
CISD1 Q9NZ45 1/20 0.34
LDLR P01130 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3973544 0.92 HSP90AA1 (0.39) HSP90AA1HSP90AB1PIM1PIM2LIPC
SCHEMBL2430530 0.86 HSP90AA1 (0.48) HSP90AA1HSP90AB1PIM1PIM2LIPC
SCHEMBL2431005 0.82 CISD1 (0.49) HSP90AA1HSP90AB1KDM4CCISD1
SCHEMBL2427599 0.82 ASPH (0.50) HSP90AA1HSP90AB1LIPCLIPGJAK1
SCHEMBL2434508 0.80 CISD1 (0.34) HSP90AA1HSP90AB1CD38CISD1
SCHEMBL3972333 0.80 HSP90AA1 (0.43) HSP90AA1HSP90AB1PIM1PIM2LIPC
SCHEMBL2426202 0.78 CISD1 (0.52) KDM4CCISD1
SCHEMBL4010874 0.78 GUCY1A1 (0.40) HSP90AA1HSP90AB1KDM4CCISD1
SCHEMBL3980350 0.78 HSP90AA1 (0.35) HSP90AA1HSP90AB1CD38CISD1
SCHEMBL2422460 0.78 JAK2 (0.40) HSP90AA1HSP90AB1JAK1JAK3JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2074120-A1 TROPANE COMPOUNDS Exelixis, Inc. (US) 2009-07-01 EP disclosed
WO-2009055077-A1 TROPANE COMPOUNDS EXELIXIS, INC. (US) 2009-04-30 WO disclosed