Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | QPCT | Q16769 | 1/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.30 |
| ▸ | USP2 | O75604 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977697 | 0.90 | CLK2 (0.35) | HSD11B1MAP3K12ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3977568 | 0.89 | HSD11B1 (0.33) | HSD11B1CYP2D6SMN1; SMN2 | |
| SCHEMBL3970810 | 0.83 | AKT1 (0.32) | HSD11B1ALDH1A1 | |
| SCHEMBL3970823 | 0.83 | MAPT (0.36) | HSD11B1SYKALDH1A1MAPK1CYP2C19 | |
| SCHEMBL2977992 | 0.82 | PDK2 (0.38) | HSD11B1 | |
| SCHEMBL3972108 | 0.82 | HSD11B1 (0.33) | HSD11B1ALDH1A1MAPK1 | |
| SCHEMBL3101115 | 0.81 | MAPT (0.40) | ALDH1A1HPGDMAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL2973860 | 0.81 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL3907137 | 0.80 | PDE2A (0.32) | — | |
| SCHEMBL3974626 | 0.79 | HSD11B1 (0.33) | HSD11B1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |