Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972651 | 1.00 | MAPT (0.51) | MAPTALDH1A1SMN1; SMN2HTTHCAR3 | |
| SCHEMBL585142 | 0.90 | HCAR3 (0.47) | MAPTALDH1A1SMN1; SMN2HTTHCAR3 | |
| SCHEMBL585141 | 0.90 | HCAR3 (0.47) | MAPTALDH1A1SMN1; SMN2HTTHCAR3 | |
| SCHEMBL4967065 | 0.88 | MAPT (0.48) | MAPTALDH1A1SMN1; SMN2HTTHCAR3 | |
| SCHEMBL584692 | 0.87 | ALDH1A1 (0.44) | MAPTALDH1A1SMN1; SMN2HTTHCAR3 | |
| SCHEMBL584693 | 0.87 | ALDH1A1 (0.44) | MAPTALDH1A1SMN1; SMN2HTTHCAR3 | |
| SCHEMBL5429501 | 0.83 | HCAR3 (0.42) | MAPTALDH1A1SMN1; SMN2HCAR3NPSR1 | |
| SCHEMBL5432649 | 0.83 | HCAR3 (0.42) | MAPTALDH1A1SMN1; SMN2HCAR3NPSR1 | |
| SCHEMBL5432643 | 0.83 | HCAR3 (0.42) | MAPTALDH1A1SMN1; SMN2HCAR3NPSR1 | |
| SCHEMBL5429492 | 0.83 | HCAR3 (0.42) | MAPTALDH1A1SMN1; SMN2HCAR3NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111865-A1 | Benzimidazole Derivatives, Compositions Containing Them, Preparation Thereof and Uses Thereof | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | US | disclosed |
| US-7501447-B2 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof | ASTRAZENECA AB (SE) | 2009-03-10 | — | — | US | disclosed |
| US-20070072853-A1 | Benzimidazole derivatives compositions containing them, preparation thereof and uses thereof | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | US | disclosed |
| US-20060205802-A1 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof | ASTRAZENECA AB (SE) | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072853-A1 | Benzimidazole derivatives compositions containing them, preparation thereof and uses thereof | RB1, CYP2C19, ADRB3 | MAPT 3892/4885ALDH1A1 165/4885SMN1; SMN2 1109/4885 |
| US-20090111865-A1 | Benzimidazole Derivatives, Compositions Containing Them, Preparation Thereof and Uses Thereof | H1-3, H1-4, CYP3A4 | MAPT 3719/4885ALDH1A1 429/4885SMN1; SMN2 1517/4885 |
| US-20060205802-A1 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof | H1-3, CYP2C19, CYP3A4 | MAPT 3771/4885ALDH1A1 370/4885SMN1; SMN2 1521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.