Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972702 | 1.00 | OPRM1 (0.46) | OPRM1ALDH1A1TDP1SPHK1TP53 | |
| SCHEMBL21670398 | 0.98 | OPRM1 (0.44) | OPRM1ALDH1A1TDP1SPHK1DNM1 | |
| SCHEMBL10655473 | 0.93 | ALDH1A1 (0.50) | OPRM1ALDH1A1TDP1SPHK1DNM1 | |
| SCHEMBL19173931 | 0.88 | OPRM1 (0.48) | OPRM1ALDH1A1TDP1SPHK1TP53 | |
| SCHEMBL4451994 | 0.88 | OPRM1 (0.48) | OPRM1ALDH1A1TDP1SPHK1TP53 | |
| SCHEMBL24919993 | 0.88 | OPRM1 (0.48) | OPRM1ALDH1A1TDP1SPHK1TP53 | |
| SCHEMBL14252507 | 0.88 | OPRM1 (0.48) | OPRM1ALDH1A1TDP1SPHK1TP53 | |
| SCHEMBL18922330 | 0.88 | OPRM1 (0.48) | OPRM1ALDH1A1TDP1SPHK1TP53 | |
| SCHEMBL19173897 | 0.88 | OPRM1 (0.48) | OPRM1ALDH1A1TDP1SPHK1TP53 | |
| Hydrochloric Acid SCHEMBL5604401 | 0.86 | OPRM1 (0.46) | OPRM1ALDH1A1TDP1SPHK1DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633697-B1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-03-11 | — | — | EP | disclosed |
| US-7417170-B2 | Process for the preparation of substituted 3-aryl-butylamine compounds | GRUENENTHAL GMBH (DE) | 2008-08-26 | — | — | US | disclosed |
| US-20060194988-A1 | Process for the preparation of substitued 3-aryl-butylamine compounds | GRUENENTHAL GMBH | 2006-08-31 | — | — | US | disclosed |
| EP-1633697-A1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS | Grünenthal GmbH (DE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108658-A1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS | Grünenthal GmbH (DE) | 2004-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194988-A1 | Process for the preparation of substitued 3-aryl-butylamine compounds | BRD3, TYR, BBOX1 | OPRM1 131/4885ALDH1A1 543/4885TDP1 2384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.