Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 2/20 | 0.56 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 7/20 | 0.54 |
| ▸ | ACHE | P22303 | 7/20 | 0.54 |
| ▸ | BCHE | P06276 | 5/20 | 0.54 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.53 |
| ▸ | CCNC | P24863 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | METAP1 | P53582 | 1/20 | 0.49 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | GRK6 | P43250 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4237965 | 0.81 | GBA1 (0.62) | JAK2METAP1PPP1CAKMT2ATDP1 | |
| SCHEMBL3975987 | 0.80 | MAPT (0.54) | CTNNB1TCF7L2KMT2AKDM4EALDH1A1 | |
| SCHEMBL3979500 | 0.78 | KDM4E (0.77) | KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL2587220 | 0.76 | RAD52 (0.70) | APPACHEBCHEKMT2AKDM4E | |
| SCHEMBL8975149 | 0.74 | HTT (0.71) | APPCCNCCDK8KDM4EALDH1A1 | |
| SCHEMBL17799807 | 0.74 | APP (0.68) | APPJAK2METAP1PPP1CAKMT2A | |
| SCHEMBL21055811 | 0.74 | APP (0.57) | APPACHEBCHEMRGPRX1CCNC | |
| SCHEMBL13406340 | 0.72 | CYP1A2 (0.57) | APPTDP1KDM4EALDH1A1 | |
| SCHEMBL7503073 | 0.72 | CCNC (0.81) | CCNCCDK8KMT2AKDM4EALDH1A1 | |
| SCHEMBL3979250 | 0.72 | GBA1 (0.56) | CCNCCDK8JAK2METAP1PPP1CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547702-B2 | 4-amino-quinazolines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-20060019974-A1 | Glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2006-01-26 | — | — | US | disclosed |
| WO-2004030672-A1 | USE OF 4 AMINO-QUINAZOLINES AS ANTI CANCER AGENTS | MERCK PATENT GMBH (DE) | 2004-04-15 | — | — | WO | disclosed |
| EP-1318984-A1 | 4-AMINO-QUINAZOLINES | MERCK PATENT GmbH (DE) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024667-A1 | 4-AMINO-QUINAZOLINES | MERCK PATENT GMBH (DE) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019974-A1 | Glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | SERPINA3, APOL1, MGAT3 | CTNNB1 1136/4885TCF7L2 1840/4885APP 2279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.