Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 8/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NNMT | P40261 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979062 | 0.93 | CISD1 (0.38) | CISD1MEN1TSHRKMT2AKDM6B | |
| SCHEMBL2428070 | 0.85 | MEN1 (0.47) | CISD1MEN1TSHRKMT2AKDM6B | |
| SCHEMBL4258452 | 0.82 | MEN1 (0.34) | CISD1MEN1TSHRKMT2AKDM6B | |
| SCHEMBL2431005 | 0.81 | CISD1 (0.49) | CISD1KDM6BKDM4CHSD17B10PLK1 | |
| SCHEMBL3975210 | 0.78 | CASR (0.33) | MEN1TSHRKMT2AKDM6BKDM4C | |
| SCHEMBL2426202 | 0.77 | CISD1 (0.52) | CISD1KDM6BKDM4CPLK1 | |
| SCHEMBL2424142 | 0.77 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1CASRL3MBTL1NNMT | |
| SCHEMBL2426568 | 0.77 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1CASRL3MBTL1NNMT | |
| SCHEMBL2424139 | 0.77 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1CASRL3MBTL1NNMT | |
| SCHEMBL29460660 | 0.77 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1CASRL3MBTL1NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |