Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.30 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2428070 | 0.83 | MEN1 (0.47) | MEN1TSHRKMT2AKDM6BKDM4C | |
| SCHEMBL3973224 | 0.82 | CISD1 (0.36) | MEN1TSHRKMT2AKDM6BKDM4C | |
| SCHEMBL2425954 | 0.82 | HSP90AA1 (0.39) | CASRMAPK14HSP90AA1HSP90AB1RXRA | |
| SCHEMBL3979062 | 0.81 | CISD1 (0.38) | MEN1TSHRKMT2AKDM6BKDM4C | |
| SCHEMBL2434508 | 0.80 | CISD1 (0.34) | MAPK14HSP90AA1HSP90AB1RXRARXRB | |
| SCHEMBL3975210 | 0.79 | CASR (0.33) | MEN1TSHRKMT2AKDM6BKDM4C | |
| SCHEMBL3975516 | 0.78 | RXRB (0.34) | KDM4CMAPK14HSP90AA1HSP90AB1RXRA | |
| SCHEMBL4010874 | 0.78 | GUCY1A1 (0.40) | KDM6BKDM4CHSP90AA1HSP90AB1NNMT | |
| SCHEMBL2422460 | 0.75 | JAK2 (0.40) | HSP90AA1HSP90AB1NNMTCISD1 | |
| SCHEMBL2424120 | 0.73 | JAK2 (0.34) | HSP90AA1HSP90AB1RXRARXRBTAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |