Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | NNMT | P40261 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | GABRE | P78334 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2428070 | 0.83 | MEN1 (0.47) | CASRMEN1TSHRKMT2AKDM4C | |
| SCHEMBL2423627 | 0.80 | HSP90AA1 (0.37) | CASRMEN1KMT2ANNMTGRM1 | |
| SCHEMBL4258452 | 0.79 | MEN1 (0.34) | CASRMEN1TSHRKMT2AKDM4C | |
| SCHEMBL3973224 | 0.78 | CISD1 (0.36) | CASRMEN1TSHRKMT2AKDM4C | |
| SCHEMBL2431005 | 0.76 | CISD1 (0.49) | KDM4CKDM6BPLK1KDM4EALDH1A1 | |
| SCHEMBL3979062 | 0.76 | CISD1 (0.38) | MEN1TSHRKMT2AKDM4CKDM6B | |
| SCHEMBL3975516 | 0.76 | RXRB (0.34) | KDM4CNNMTGABRPGABRDGABRA1 | |
| SCHEMBL2422460 | 0.75 | JAK2 (0.40) | NNMTGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2434508 | 0.75 | CISD1 (0.34) | KDM4EALDH1A1 | |
| SCHEMBL2430012 | 0.74 | HSP90AA1 (0.35) | CASRMEN1KMT2ANNMTGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |