Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2107138 | 0.98 | HPGD (0.59) | HPGDALDH1A1USP2GAAMAPK1 | |
| SCHEMBL1723442 | 0.83 | POLB (0.51) | HPGDALDH1A1NPC1CYP2C9 | |
| SCHEMBL2425734 | 0.81 | SIGMAR1 (0.61) | HPGDALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL11790594 | 0.77 | HPGD (0.55) | HPGDALDH1A1USP2GAAMAPK1 | |
| SCHEMBL22365689 | 0.74 | ALDH1A1 (0.63) | HPGDALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL27798296 | 0.74 | HPGD (0.63) | HPGDALDH1A1USP2GAAMAPK1 | |
| SCHEMBL2182275 | 0.74 | HPGD (0.63) | HPGDALDH1A1USP2GAAMAPK1 | |
| SCHEMBL11482052 | 0.74 | HPGD (0.52) | HPGDALDH1A1USP2GAAMAPK1 | |
| SCHEMBL11482047 | 0.74 | HPGD (0.52) | HPGDALDH1A1USP2GAAMAPK1 | |
| SCHEMBL254870 | 0.73 | HPGD (0.96) | HPGDALDH1A1USP2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |