Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 15/20 | 0.47 |
| ▸ | HRH1 | P35367 | 4/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3997486 | 0.82 | SSTR5 (0.52) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL3971809 | 0.82 | SSTR5 (0.52) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL2421567 | 0.77 | SSTR5 (0.63) | SSTR5HRH1HTR2BDRD2DRD4 | |
| SCHEMBL2420424 | 0.77 | SSTR5 (0.63) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4237355 | 0.74 | SSTR5 (0.49) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL3977626 | 0.73 | SSTR5 (0.49) | SSTR5HRH1HTR2BMEN1KMT2A | |
| SCHEMBL2420530 | 0.72 | SSTR5 (0.61) | SSTR5HRH1HTR2BKCNH2 | |
| SCHEMBL3977762 | 0.72 | SSTR5 (0.52) | SSTR5HRH1HTR2BMEN1KMT2A | |
| SCHEMBL3977776 | 0.72 | SSTR5 (0.50) | SSTR5HRH1HTR2BMEN1KMT2A | |
| SCHEMBL3971377 | 0.72 | SSTR5 (0.41) | SSTR5HRH1HTR2BSSTR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |