SCHEMBL3973482

SCHEMBL3973482

CCc1nc2c(-c3c(S)nnn3-c3cc(CC)c(O)cc3O)cccc2[nH]1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.39
MAPT P10636 2/20 0.39
LMNA P02545 2/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
HSD17B10 Q99714 1/20 0.39
DDAH1 O94760 1/20 0.34
CHEK1 O14757 1/20 0.33
GAA P10253 2/20 0.31
HSP90AA1 P07900 3/20 0.31
PAX8 Q06710 1/20 0.31
DAO P14920 1/20 0.31
DDO Q99489 1/20 0.31
PDE10A Q9Y233 1/20 0.30
HTR6 P50406 1/20 0.30
ALOX15 P16050 1/20 0.30
ALOX12 P18054 1/20 0.30
JAK2 O60674 1/20 0.30
JAK1 P23458 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1148697 0.81 ALDH1A1 (0.41) KDM4EMAPTLMNAALDH1A1HPGD
SCHEMBL1148321 0.80 HSP90AA1 (0.34) KDM4EMAPTLMNAALDH1A1HPGD
SCHEMBL3973742 0.79 DAO (0.34) KDM4EMAPTLMNAALDH1A1HPGD
SCHEMBL3973855 0.77 GRIN2D (0.34) KDM4EMAPTLMNAALDH1A1HPGD
SCHEMBL1148442 0.76 HSP90AA1 (0.35) MAPTALDH1A1HSD17B10GAAHSP90AA1
SCHEMBL1148636 0.75 IDH1 (0.37) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL2596688 0.73 KDM4E (0.38) KDM4EMAPTLMNAALDH1A1HPGD
SCHEMBL1148410 0.73 KDM4E (0.32) KDM4EMAPTHPGDHSD17B10GAA
SCHEMBL1148348 0.73 ALDH1A1 (0.38) KDM4EMAPTALDH1A1HPGDHSD17B10
SCHEMBL1147877 0.72 CYP2C9 (0.34) MAPTALDH1A1HPGDTSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2054059-A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY Synta Pharmaceuticals Corporation (US) 2009-05-06 EP claimed
WO-2008021364-A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP. (US) 2008-02-21 WO claimed
EP-1817295-A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY Synta Pharmaceuticals Corporation (US) 2007-08-15 EP claimed
WO-2006055760-A9 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP (US) 2006-09-21 WO claimed
WO-2006055760-A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP. (US) 2006-05-26 WO claimed
WO-2008112199-A1 METHOD FOR INHIBITING TOPOISOMERASE II SYNTA PHARMACEUTICALS CORP. (US) 2008-09-18 WO disclosed
WO-2007139952-A2 METHOD FOR THE PREPARATION OF TRIAZOLE COMPOUNDS WITH HSP90 MODULATING ACTIVITY SYNTA PHARMACEUTICALS CORP. (US) 2007-12-06 WO disclosed