Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | DDO | Q99489 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974314 | 0.90 | DAO (0.34) | DAODDOHSP90AA1KDM4EALDH1A1 | |
| SCHEMBL3978017 | 0.84 | HSP90AA1 (0.34) | HSP90AA1 | |
| SCHEMBL3972901 | 0.84 | HSP90AA1 (0.34) | DAODDOHSP90AA1KDM4EALDH1A1 | |
| SCHEMBL3980046 | 0.83 | SLC5A1 (0.32) | HSP90AA1 | |
| SCHEMBL1148321 | 0.83 | HSP90AA1 (0.34) | HSP90AA1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL3973855 | 0.83 | GRIN2D (0.34) | DAODDOHSP90AA1KDM4EALDH1A1 | |
| SCHEMBL1148697 | 0.81 | ALDH1A1 (0.41) | HSP90AA1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL1148442 | 0.81 | HSP90AA1 (0.35) | HSP90AA1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL1148410 | 0.79 | KDM4E (0.32) | HSP90AA1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL3973482 | 0.79 | KDM4E (0.39) | DAODDOHSP90AA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054059-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2009-05-06 | — | — | EP | claimed |
| WO-2008021364-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-21 | — | — | WO | claimed |
| EP-1817295-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2007-08-15 | — | — | EP | claimed |
| WO-2006055760-A9 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP (US) | 2006-09-21 | — | — | WO | claimed |
| WO-2006055760-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2006-05-26 | — | — | WO | claimed |
| WO-2008112199-A1 | METHOD FOR INHIBITING TOPOISOMERASE II | SYNTA PHARMACEUTICALS CORP. (US) | 2008-09-18 | — | — | WO | disclosed |