Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 8/20 | 0.54 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2429407 | 0.96 | CISD1 (0.53) | CISD1KDM6BKDM4CHCAR3CA12 | |
| SCHEMBL2431511 | 0.90 | CISD1 (0.51) | CISD1KDM6BKDM4CHCAR3CA12 | |
| SCHEMBL2426202 | 0.85 | CISD1 (0.52) | CISD1KDM6BKDM4CHCAR3PLK1 | |
| SCHEMBL3979546 | 0.84 | CISD1 (0.51) | CISD1KDM6BKDM4CHCAR3PLK1 | |
| SCHEMBL1884483 | 0.82 | CISD1 (0.63) | CISD1KDM6BKDM4CHCAR3PLK1 | |
| SCHEMBL3974778 | 0.81 | CISD1 (0.48) | CISD1KDM6BKDM4CHCAR3PLK1 | |
| SCHEMBL2422093 | 0.78 | APEX1 (0.36) | CISD1CA12CA1CA2CA3 | |
| SCHEMBL2425743 | 0.78 | MAPK8 (0.42) | CISD1CA12CA1CA2CA3 | |
| SCHEMBL2428525 | 0.78 | TSHR (0.46) | CISD1KDM6BKDM4CHCAR3CA12 | |
| SCHEMBL3141041 | 0.77 | HCAR3 (0.57) | CISD1KDM6BKDM4CHCAR3PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |