Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 4/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979546 | 0.83 | CISD1 (0.51) | CISD1KDM6BKDM4CPLK1HCAR3 | |
| SCHEMBL2426202 | 0.82 | CISD1 (0.52) | CISD1KDM6BKDM4CPLK1HCAR3 | |
| SCHEMBL3973539 | 0.81 | CISD1 (0.54) | CISD1KDM6BKDM4CPLK1HCAR3 | |
| SCHEMBL1884483 | 0.79 | CISD1 (0.63) | CISD1KDM4EALDH1A1HPGDKDM6B | |
| SCHEMBL2427452 | 0.77 | HCAR3 (0.37) | KDM4EALDH1A1HCAR3 | |
| SCHEMBL2421470 | 0.77 | POLB (0.39) | HCAR3 | |
| SCHEMBL3141157 | 0.77 | HCAR3 (0.37) | KDM4EALDH1A1HCAR3 | |
| SCHEMBL5325478 | 0.77 | ALDH1A1 (0.47) | CISD1ALDH1A1PLK1 | |
| SCHEMBL2429407 | 0.76 | CISD1 (0.53) | CISD1KDM6BKDM4CHCAR3 | |
| SCHEMBL16737192 | 0.75 | PLK1 (0.53) | CISD1KDM4EALDH1A1HPGDKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |