Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 11/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.40 |
| ▸ | REN | P00797 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973837 | 0.94 | REN (0.40) | SLC6A2SLC6A4RENALOX15HTR2A | |
| SCHEMBL3972940 | 0.93 | ALOX15 (0.40) | SLC6A2SLC6A4RENALOX15HTR2A | |
| SCHEMBL3974580 | 0.92 | REN (0.41) | SLC6A2SLC6A4RENHTR2ANPSR1 | |
| SCHEMBL3972539 | 0.90 | REN (0.44) | SLC6A2SLC6A4REN | |
| SCHEMBL3977756 | 0.85 | REN (0.41) | RENHTR2A | |
| SCHEMBL3979706 | 0.84 | REN (0.44) | SLC6A2SLC6A4RENSLC6A3 | |
| SCHEMBL3972591 | 0.83 | REN (0.43) | RENNPSR1 | |
| SCHEMBL3968591 | 0.83 | GAA (0.38) | SLC6A2SLC6A4HTR2ASLC6A3 | |
| SCHEMBL3978538 | 0.82 | REN (0.43) | SLC6A2SLC6A4RENALOX15HTR2A | |
| SCHEMBL4702309 | 0.81 | REN (0.44) | SLC6A2SLC6A4RENALOX15HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |