Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972591 | 0.94 | REN (0.43) | RENSMN1; SMN2FLT4PTK2TACR1 | |
| SCHEMBL3974580 | 0.93 | REN (0.41) | RENALDH1A1FLT4PTK2HTR2A | |
| SCHEMBL3972940 | 0.92 | ALOX15 (0.40) | RENFLT4PTK2HTR2AKDM4E | |
| SCHEMBL3970028 | 0.92 | ALDH1A1 (0.37) | ALDH1A1HTTSMN1; SMN2HTR2ATACR1 | |
| SCHEMBL3977946 | 0.91 | MAPT (0.40) | ALDH1A1HTTSMN1; SMN2TACR1KDM4E | |
| SCHEMBL3979706 | 0.86 | REN (0.44) | RENSMN1; SMN2FLT4PTK2TACR1 | |
| SCHEMBL3972539 | 0.86 | REN (0.44) | RENSMN1; SMN2FLT4PTK2TACR1 | |
| SCHEMBL3973369 | 0.85 | REN (0.43) | RENALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL3973810 | 0.85 | SLC6A2 (0.40) | RENHTR2A | |
| SCHEMBL3973837 | 0.85 | REN (0.40) | RENFLT4PTK2HTR2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |