Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 9/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973959 | 0.87 | JAK3 (0.38) | JAK3BTKCCNT1CDK1CCNB1 | |
| SCHEMBL13883570 | 0.84 | BACE1 (0.41) | JAK3BTKJAK2HDAC1HDAC6 | |
| SCHEMBL3966066 | 0.84 | AXL (0.41) | JAK3BTKCDK7CDK9JAK2 | |
| SCHEMBL3969959 | 0.82 | JAK3 (0.38) | JAK3BTKCCNT1CDK1CCNB1 | |
| SCHEMBL3969991 | 0.81 | JAK3 (0.36) | JAK3BTKCCNT1CDK1CCNB1 | |
| SCHEMBL3971282 | 0.80 | CCNT1 (0.36) | JAK3BTKCCNT1CDK1CCNB1 | |
| SCHEMBL3974132 | 0.79 | JAK3 (0.43) | JAK3BTKCCNT1CDK1CCNB1 | |
| SCHEMBL13883580 | 0.75 | AXL (0.46) | JAK3JAK2HDAC1HDAC6JAK1 | |
| SCHEMBL3970514 | 0.74 | PDGFRB (0.42) | JAK3BTKPDPK1 | |
| SCHEMBL3969605 | 0.74 | JAK3 (0.39) | JAK3BTKJAK2AURKBPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |