Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | YES1 | P07947 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.31 |
| ▸ | CHRNG | P07510 | 1/20 | 0.31 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969959 | 0.86 | JAK3 (0.38) | JAK3BTKAURKBCCNT1CDK1 | |
| SCHEMBL3971282 | 0.86 | CCNT1 (0.36) | JAK3BTKAURKBCCNT1CDK1 | |
| SCHEMBL13883619 | 0.84 | AXL (0.43) | YES1PDGFRBEPHB4 | |
| SCHEMBL3973959 | 0.82 | JAK3 (0.38) | JAK3BTKAURKBCCNT1CDK1 | |
| SCHEMBL3974063 | 0.81 | JAK3 (0.40) | JAK3BTKAURKBCCNT1CDK1 | |
| SCHEMBL3974132 | 0.78 | JAK3 (0.43) | JAK3BTKAURKBCCNT1CDK1 | |
| SCHEMBL3969296 | 0.75 | BACE1 (0.40) | JAK3CDK1JAK2LTA4H | |
| SCHEMBL3969605 | 0.75 | JAK3 (0.39) | JAK3BTKAURKBPDPK1JAK1 | |
| SCHEMBL13883724 | 0.74 | AXL (0.47) | — | |
| SCHEMBL3966481 | 0.74 | BACE1 (0.48) | JAK3YES1EPHB4JAK2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |